GV (nerve agent)

GV
	Ball-and-stick model of GV
	Skeletal formula of GV
Names
	IUPAC name 2-(Dimethylamino)ethyl N,N-dimethylphosphoramidofluoridate
	Other names EA-5365; Deanylfluorotabun; G-agent P
Identifiers
CAS Number	141102-74-1 ;
3D model (JSmol)	Interactive image;
ChemSpider	112656 ;
PubChem CID	132333;
CompTox Dashboard (EPA)	DTXSID30930987 ;
	InChI InChI=1S/C6H16FN2OP/c1-8(2)5-6-11(7,10)9(3)4/h5-6H2,1-4H3 Key: JJHAGEZAXYOCMC-UHFFFAOYSA-N ; InChI=1/C6H16FN2OP/c1-8(2)5-6-11(7,10)9(3)4/h5-6H2,1-4H3 Key: JJHAGEZAXYOCMC-UHFFFAOYAS;
	SMILES FP(=O)(N(C)C)CCN(C)C;
Properties
Chemical formula	C6H16FN2O2P
Molar mass	198.176 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

GV (IUPAC name: 2-(Dimethylamino)ethyl N,N-dimethylphosphoramidofluoridate), also known as EA-5365 and GP (USACC cryptonym), is an organophosphate nerve agent. GV is a part of a series of nerve agents with properties similar to the "G-series" and "V-series". It is a potent acetylcholinesterase inhibitor with properties similar to other nerve agents. GV is structurally a derivative of the nerve agent tabun, being closely structurally related to fluorotabun, differing from the latter by the replacement of a proton on the alpha carbon of the alkoxide group by a dimethylamino group and presenting a toxicity only lower than that of VX.^[1]^[2]

Treatment for poisoning with GV involves drugs such as atropine, benactyzine, obidoxime, and HI-6.^[3]^[4]

^ Holmstedt, Bo (1963), Koelle, George B. (ed.), "Structure-Activity Relationships of the Organophosphorus Anticholinesterase Agents", Cholinesterases and Anticholinesterase Agents, Handbook of Experimental Pharmacology, vol. 15, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 428–485, doi:10.1007/978-3-642-99875-1_9, ISBN 978-3-642-99877-5, retrieved 2025-03-11 {{citation}}: ISBN / Date incompatibility (help)
^ Ellison, D. Hank (2008). Handbook of chemical and biological warfare agents (2nd ed.). Boca Raton: CRC Press. ISBN 978-1-4200-0329-1.
^ Fusek J, Bajgar J (1994). "Treatment of intoxication with GV compound in laboratory rats". Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 37 (2): 57–62. PMID 7784799.
^ Kassa J, Bajgar J (1996). "Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice". Acta Medica (Hradec Kralove). 39 (1): 27–30. PMID 9106387.

[1] Holmstedt, Bo (1963), Koelle, George B. (ed.), "Structure-Activity Relationships of the Organophosphorus Anticholinesterase Agents", Cholinesterases and Anticholinesterase Agents, Handbook of Experimental Pharmacology, vol. 15, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 428–485, doi:10.1007/978-3-642-99875-1_9, ISBN 978-3-642-99877-5, retrieved 2025-03-11 {{citation}}: ISBN / Date incompatibility (help)

[2] Ellison, D. Hank (2008). Handbook of chemical and biological warfare agents (2nd ed.). Boca Raton: CRC Press. ISBN 978-1-4200-0329-1.

[3] Fusek J, Bajgar J (1994). "Treatment of intoxication with GV compound in laboratory rats". Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 37 (2): 57–62. PMID 7784799.

[4] Kassa J, Bajgar J (1996). "Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice". Acta Medica (Hradec Kralove). 39 (1): 27–30. PMID 9106387.

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GV (nerve agent)

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