Cyclen

Cyclen
Names
	Preferred IUPAC name 1,4,7,10-Tetrazacyclododecane
	Other names Tetraaza-12-crown-4
Identifiers
CAS Number	294-90-6 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEBI	CHEBI:37391 ;
ChEMBL	ChEMBL19880 ;
ChemSpider	58488 ;
ECHA InfoCard	100.102.391
PubChem CID	64963;
UNII	964584YO2O ;
CompTox Dashboard (EPA)	DTXSID60183621 ;
	InChI InChI=1S/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2 Key: QBPPRVHXOZRESW-UHFFFAOYSA-N ; InChI=1/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2 Key: QBPPRVHXOZRESW-UHFFFAOYAQ;
	SMILES N1CCNCCNCCNCC1; C1CNCCNCCNCCN1;
Properties
Chemical formula	C8H20N4
Molar mass	172.276 g·mol−1
Appearance	White solid
Melting point	110–113 °C (230–235 °F; 383–386 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Cyclen (1,4,7,10-tetraazacyclododecane) is an aza-crown ether with the formula (CH₂CH₂NH)₄. It is a white solid. It forms coordination complexes with metal cations and is used to synthesize the chelating agent DOTA which has several medical applications. Being structurally simple, symmetrical, and polyfunctional, cyclen has been widely investigated.^[1]

^ Lejault, Pauline; Duskova, Katerina; Bernhard, Claire; Valverde, Ibai E.; Romieu, Anthony; Monchaud, David (2019). "The Scope of Application of Macrocyclic Polyamines Beyond Metal Chelation" (PDF). European Journal of Organic Chemistry. 2019 (36): 6146–6157. doi:10.1002/ejoc.201900870. S2CID 201220297.

[1] Lejault, Pauline; Duskova, Katerina; Bernhard, Claire; Valverde, Ibai E.; Romieu, Anthony; Monchaud, David (2019). "The Scope of Application of Macrocyclic Polyamines Beyond Metal Chelation" (PDF). European Journal of Organic Chemistry. 2019 (36): 6146–6157. doi:10.1002/ejoc.201900870. S2CID 201220297.

[1]

Cyclen

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